During the wet granulation process, you begin with the blend for the supplement ready and mixed. Then the mixed blend will then have water added to it.
The water will wet the powder and add an immobile layer of water between particles. With more and more water being added to the powder, it will continually grow the layer of water gets wider and will ultimately pass through the pores of the particles.
To then get the water out of the blend, it will be evaporated and will result in a very strong level of adhesion for the particles, which will result in the particles grouping in and becoming larger. The size of particles will be affected by many factors such as blend, density, and the type and amount of binders added are a few of those.
The final step will be drying. For small batches, a tray drying oven is used, but for more automation and larger batches, fluid bed dryers are used. These driers utilize a stream of warm and dehumidified air running through the base of the drying chamber. To keep the powder from being pushed out of the chamber, a fine mesh is in place to keep all powder where it needs to be.